From the Aprehend web site:

Natural Biopesticide

Aprehend® is composed of Beauveria bassiana fungal spores applied in a proprietary and patented formulation.

Aprehend® is sprayed strategically in narrow bands where bed bugs are known to walk.

Direct spray contact is not necessary. Bed bugs of all life stages, sex, or feeding status are killed within four to ten days following short-term contact with a treated surface.

The fungal spores germinate within 20 hours of contact and then penetrate the cuticle of the bed bug and colonize inside, resulting in death.

Control Treatment

Extensive laboratory studies have demonstrated that when bed bugs cross a treated surface, they pick up and carry fungal spores back to the harborage or nesting area.

The spores are easily transferred to others in the colony. All bed bugs that come into contact with the fungal spores die within four to ten days.

This process of acquiring spores from a surface treated with Aprehend® and transferring them to the colony is repeated each night. This happens until the population is eliminated.

Aprehend® doesn’t kill immediately. This is intentional and strategic. We want every bed bug to come into contact with the fungal spores first. Only then does the population become infected and die.

If you’ve been looking for products to kill bed bugs and ways to treat bed bugs effectively, look no further than Aprehend®. The spray residue remains effective for up to three months.

Unlike chemical insecticides, only one application is required to treat an infestation.

Proactive Treatment

Due to its excellent long-term activity, Aprehend® will provide three months’ protection from the establishment of bed bug infestations.

A regular (quarterly) treatment with Aprehend® offers hotels and motels the first and only effective method to protect against bed bugs and the associated lawsuits, loss of reputation, and remediation costs associated with bed bug infestations.

There are plenty of online articles explaining to travelers how to search their hotel or motel rooms for bed bugs, or signs of them.

Those articles advise customers to notify management immediately if they find bed bugs. They also say of course to ask to be moved to a different room.